反应详情

56 g 7-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran are dissolved in 200 ml 2-methyltetrahydrofuran, 58 g N-bromosuccinimide are added portion wise, while keeping the temperature of the reaction mixture below 50° C., and the reaction is stirred for one hour at RT. Water and diethyl ether are added to the reaction mixture, the phases are separated, the organic phase is washed with 1 M aqueous sodium carbonate solution, dried over MgSO4, and the solvent is removed under reduced pressure. The resulting crude product is purified by distillation under vacuum yielding 5-bromo-7-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran.

1. customthe temperature of the reaction mixture below 50° C.
2. customthe phases are separated
3. washthe organic phase is washed with 1 M aqueous sodium carbonate solution
4. dry with materialdried over MgSO4
5. customthe solvent is removed under reduced pressure
6. distillationThe resulting crude product is purified by distillation under vacuum