HRID1914378

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2782904

4-Bromo-2-fluorobenzotrifluoride

C7H3BrF4

结构：COC(=O)CCNC(=O)c1ccc(C(CCCC(F)(F)F)Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cc1

HCID67153418

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CCNC(=O)c1ccc(C(CCCC(F)(F)F)Oc2ccc(-c3ccc(C(F)(F)F)c(F)c3)cc2)cc1

HCID59518110

未命名化合物

PROCEDURE

实验过程

The title compound is prepared in a manner substantially similar to Example 359 starting from 3-(4-{5,5,5-trifluoro-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-pentyl}-benzoylamino)-propionic acid methyl ester and 4-bromo-2-fluoro-1-trifluoromethyl-benzene. MS: 570.2 [M−H]−.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-26b9279f80374768b8bc8e0597d31a64
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08609892B2
来源说明: uspto-grants-2013_12

反应 SMILES

C[O:2][C:3](=[O:39])[CH2:4][CH2:5][NH:6][C:7](=[O:38])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:22][C:23]2[CH:28]=[CH:27][C:26](B3OC(C)(C)C(C)(C)O3)=[CH:25][CH:24]=2)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:10][CH:9]=1.Br[C:41]1[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[C:43]([F:51])[CH:42]=1>>[F:20][C:18]([F:19])([F:21])[CH2:17][CH2:16][CH2:15][CH:14]([C:11]1[CH:10]=[CH:9][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:39])=[O:38])=[CH:13][CH:12]=1)[O:22][C:23]1[CH:28]=[CH:27][C:26]([C:41]2[CH:46]=[CH:45][C:44]([C:47]([F:49])([F:50])[F:48])=[C:43]([F:51])[CH:42]=2)=[CH:25][CH:24]=1