HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzotrifluoride → Racemic 3-{4-[5,5,5-trifluoro-1-(3'-fluoro-4'-trifluoromethyl-biphenyl-4-yloxy)-pentyl]-benzoylamino}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzotrifluoride | HCID 2782904 | — |
| Reactant | 3-(4-{5,5,5-Trifluoro-1-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenoxy]-pentyl}-benzoylamino)-propionic acid methyl ester | HCID 67153418 | — |
| Product | Racemic 3-{4-[5,5,5-trifluoro-1-(3'-fluoro-4'-trifluoromethyl-biphenyl-4-yloxy)-pentyl]-benzoylamino}-propionic acid | HCID 59518110 | — |
Reaction Steps
The title compound is prepared in a manner substantially similar to Example 359 starting from 3-(4-{5,5,5-trifluoro-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-pentyl}-benzoylamino)-propionic acid methyl ester and 4-bromo-2-fluoro-1-trifluoromethyl-benzene. MS: 570.2 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609892B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-26b9279f80374768b8bc8e0597d31a64 |
| Source note | uspto-grants-2013_12 |