Sodium Azide → HCID 53248046, compound

HRID 1914439Notes

Reaction equation

HRID 1914439 reaction equation
Br[CH2:2][CH2:3][CH:4]([S:9]([OH:12])(=[O:11])=[O:10])[C:5]([O:7][CH3:8])=[O:6].[N-:13]=[N+:14]=[N-:15].[Na+]>CN(C=O)C>[N:13]([CH2:2][CH2:3][CH:4]([S:9]([OH:12])(=[O:11])=[O:10])[C:5]([O:7][CH3:8])=[O:6])=[N+:14]=[N-:15]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 53247992HCID 53247992, compound

Product 1

HCID 53248046HCID 53248046, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Methyl 4-bromo-2-sulfo-butyrate (1.07 g, 4.11 mmol) and sodium azide (0.70 g (10.7 mmol) in DMF (50 ml) was stirred overnight. The mixture was evaporated and purified by SiO2 chromatography and eluted with 1:5:0.01 CH3OH/CH2Cl2/HAc and crystallized with CH3OH/Toluene/Hexane to afford 1.00 g (95%) of the title compound. m.p=267-272° C. (decomp). 1H NMR (DMF-d7): 12.06 (br, 1H), 3.65 (s, 3H), 3.59 (dd, 1H, J=5.4, 8.9 Hz), 3.47 (m, 2H), 2.24 (m, 2H). 13C NMR 171.10, 64.29, 52.24, 50.64, 21.35. ESI MS m/z+ 267.9 (M+2Na—H), m/z− 222.0 (M−H). HRMS m/z− (C5H9N3O5S—H) calcd 222.0185. found 222.0179.

Workup

  1. customThe mixture was evaporated
  2. custompurified by SiO2 chromatography
  3. washeluted with 1:5:0.01 CH3OH/CH2Cl2/HAc
  4. customcrystallized with CH3OH/Toluene/Hexane

Sources & evidence

ORD record
ord-f84164dd7df54cb7a3882b00d8e41183
Source dataset
uspto-grants-2013_12
Patent number
US08613930B2

Reaction notes

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