HuagongsheHuagongshe Chemistry Print Report · For research reference only
[2-Benzylsulfanyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-ylmethyl]-carbamic acid tert-butyl ester → C-[2-Benzylsulfanyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-yl]-methylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [2-Benzylsulfanyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-ylmethyl]-carbamic acid tert-butyl ester | HCID 66832575 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | C-[2-Benzylsulfanyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-yl]-methylamine | HCID 66832492 | — |
Reaction Steps
[2-benzylsulfanyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-ylmethyl]-carbamic acid tert-butyl ester was diluted with 4N HCl in dioxane (20 mL) at rt. After 30 min. the mixture was concentrated and the resulting solid was used without further purification. MS (ESI): mass calcd. for C19H16F3N3S, 373.2; m/z found, 374.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614201B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-262f5a4559ae4f96b5c4b417923407e6 |
| Source note | uspto-grants-2013_12 |