Hydrazine hydrate (1:1) → HCID 66832597, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[2-pyridin-3-yl-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-ylmethyl]-isoindole-1,3-dione (0.1 g, 0.217 mmol) in ethanol (5 mL) was added hydrazine mono-hydrate (14 μl, 0.434 mmol) at rt. The resulting mixture was heated to 90° C. for 12 h then cooled to rt. The resulting mixture was concentrated and taken on crude to the next step. MS (ESI): mass calcd. for C17H13F3N4, 330.1; m/z found, 331.2 [M+H]+.

Provenance & Evidence