Hydrazine hydrate (1:1) → HCID 66832597, compound

HRID 1914514Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]=[C:11]([CH2:13][N:14]3C(=O)C4C(=CC=CC=4)C3=O)[CH:10]=[C:9]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=3)[N:8]=2)[CH:2]=1.O.NN>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]=[C:11]([CH2:13][NH2:14])[CH:10]=[C:9]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:32])[F:33])=[CH:27][CH:26]=3)[N:8]=2)[CH:2]=1

Participants

Conditions

Temperature: 90 °C

Procedure

To a solution of 2-[2-pyridin-3-yl-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-ylmethyl]-isoindole-1,3-dione (0.1 g, 0.217 mmol) in ethanol (5 mL) was added hydrazine mono-hydrate (14 μl, 0.434 mmol) at rt. The resulting mixture was heated to 90° C. for 12 h then cooled to rt. The resulting mixture was concentrated and taken on crude to the next step. MS (ESI): mass calcd. for C17H13F3N4, 330.1; m/z found, 331.2 [M+H]+.

Workup

temperaturethen cooled to rt
concentrationThe resulting mixture was concentrated

Sources & evidence

ORD record: ord-63b69dc95743431ab7a60d329a9bc91f
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08614201B2

Reaction notes

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