Dimethylamine, hydrochloride → HCID 178483261, compound

HRID 1914636Notes

Reaction equation

[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:3]=1[C:4]([NH:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([CH2:13][NH:14][C:15]2[CH:20]=[CH:19][C:18]([CH:21]=O)=[CH:17][N:16]=2)[CH2:9][CH2:8]1)=[O:5].Cl.[CH3:32][NH:33][CH3:34]>>[ClH:1].[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:3]=1[C:4]([NH:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([CH2:13][NH:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][N:33]([CH3:34])[CH3:32])=[CH:17][N:16]=2)[CH2:9][CH2:8]1)=[O:5]

Participants

Reactant 2

HCID 10473Dimethylamine, hydrochloride

HCID 178519698HCID 178519698, compound

Product 1

HCID 178483261HCID 178483261, compound

Procedure

The title compound is prepared from Trans-2-Chloro-N-{-4-[(5-formyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide and dimethylamine hydrochloride analogously to Example 1.

Sources & evidence

ORD record: ord-c4ffd63519a9435aab5b2dcdb215a635
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08614213B2

Reaction notes

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