反应详情

A mixture comprising toluene-4-sulfonic acid 4-benzylamino-3-methyl-cyclohexylmethyl ester (350 mg, 0.90 mmol), aniline (126, mg, 1.35 mmol) and potassium carbonate (250 mg, 1.80 mmol) in MeCN (1 mL) is heated using microwave radiation at 180° C. for 1 hour. The reaction mixture is partitioned between DCM and water and passed through a phase separator. The solvent is removed in vacuo and purification of the crude residue by chromatography on silica eluting with iso-hexane:EtOAc (25:1 increasing to 10:1) affords the title compound. [MH+309.34].

1. customat 180° C.
2. customfor 1 hour
3. customThe reaction mixture is partitioned between DCM and water
4. customThe solvent is removed in vacuo and purification of the crude residue by chromatography on silica eluting with iso-hexane:EtOAc (25:1 increasing to 10:1)