反应详情

8-Iodo-1-trityl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (291 mg, 0.5 mmol) in DCM (10 mL) was treated with trifluoroacetic acid (0.5 mL). The resulting mixture was stirred at room temperature for 1 hour. DCM (40 mL) was added and the organic phase was washed with saturated solution of sodium hydrogen carbonate, then with brine, dried over sodium sulfate and concentrated. The crude solid was purified by flash chromatography on silica gel (eluant: DCM/EtOH 90/10) to afford 143 mg of the title compound (84% yield).

1. washthe organic phase was washed with saturated solution of sodium hydrogen carbonate
2. dry with materialwith brine, dried over sodium sulfate
3. concentrationconcentrated
4. customThe crude solid was purified by flash chromatography on silica gel (eluant: DCM/EtOH 90/10)