HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[2-trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenyl]-acetamide | HCID 59454307 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt | HCID 86644660 | — |
Reaction Steps
A solution of N-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenyl]-acetamide (4.75 g, 15 mmol) in EtOH (100 mL) was treated with HCl 37% (35 mL). After 1 h under reflux the mixture was concentrated and tritured with hexane to give in quantitative yield, 5.74 g of 5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine trihydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614220B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-c84695d9b1f642eabdb7a615676cc2e7 |
| Source note | uspto-grants-2013_12 |