Hydrochloric Acid → 2-Trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt

HRID 1914748Notes

Reaction equation

HRID 1914748 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]([O:18][C:19]([F:22])([F:21])[F:20])=[C:12]([NH:14]C(=O)C)[CH:13]=2)[CH2:4][CH2:3]1.[ClH:23]>CCO>[ClH:23].[ClH:23].[ClH:23].[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]([O:18][C:19]([F:22])([F:20])[F:21])=[C:12]([NH2:14])[CH:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59454307N-[2-trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenyl]-acetamide

Product 1

HCID 866446602-Trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of N-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenyl]-acetamide (4.75 g, 15 mmol) in EtOH (100 mL) was treated with HCl 37% (35 mL). After 1 h under reflux the mixture was concentrated and tritured with hexane to give in quantitative yield, 5.74 g of 5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine trihydrochloride salt.

Workup

  1. temperatureAfter 1 h under reflux the mixture
  2. concentrationwas concentrated and tritured with hexane

Sources & evidence

ORD record
ord-c84695d9b1f642eabdb7a615676cc2e7
Source dataset
uspto-grants-2013_12
Patent number
US08614220B2

Reaction notes

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