反应详情

A solution of N-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenyl]-acetamide (4.75 g, 15 mmol) in EtOH (100 mL) was treated with HCl 37% (35 mL). After 1 h under reflux the mixture was concentrated and tritured with hexane to give in quantitative yield, 5.74 g of 5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine trihydrochloride salt.

1. temperatureAfter 1 h under reflux the mixture
2. concentrationwas concentrated and tritured with hexane