1-(4-Methoxy-3-nitrophenyl)-4-methylpiperazine → HCID 24994141, compound

HRID 1914752Notes

Reaction equation

HRID 1914752 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]2)=[CH:5][C:4]=1[N+:16]([O-])=O>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]2)=[CH:5][C:4]=1[NH2:16]

Participants

4

Reactant 1

HCID 594418861-(4-Methoxy-3-nitrophenyl)-4-methylpiperazine

Product 1

HCID 24994141HCID 24994141, compoundYield 90.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-(4-methoxy-3-nitro-phenyl)-4-methyl-piperazine (1.0 g, 4.0 mmol) in MeOH (100 mL) in the presence of Pd/C 10% (150 mg) was hydrogenated at 35 psi for 2 h. The mixture was filtered over a pad of celite and the solution was concentrated to afford 0.8 g (90% yield) of the title compound.

Workup

  1. filtrationThe mixture was filtered over a pad of celite
  2. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-da2faf56a50642e2a67cda9ee67d967e
Source dataset
uspto-grants-2013_12
Patent number
US08614220B2

Reaction notes

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