HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 86677207, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,2,2-trifluoro-N-(4-phenylphenyl)acetamide | HCID 261961 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 86677207 | HCID 86677207 | — |
Reaction Steps
13.00 g (49.0 mmol) N-(Biphenyl-4-yl)-2,2,2-trifluoro-acetamide (II.1.a) is dissolved in 200 mL acetone and 13.5 g (98.0 mmol) potassium carbonate is added. 3.50 mL (55.7 mmol) methyl iodide is added and the mixture is stirred at RT over night. The solvent is evaporated. The residue is taken up in water and extracted with ethyl acetate. The organic phase is dried and the solvent is evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614238B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-a56ad138d1d54046b17a39680d8b0f0e |
| Source note | uspto-grants-2013_12 |