Methyl iodide → HCID 86677207, compound

HRID 1914805Notes

Reaction equation

HRID 1914805 reaction equation
[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][C:4]([NH:7][C:8](=[O:13])[C:9]([F:12])([F:11])[F:10])=[CH:3][CH:2]=1.[C:20](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[C:1]1([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:2]=[CH:3][C:4]([N:7]([CH3:20])[C:8](=[O:13])[C:9]([F:11])([F:12])[F:10])=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 2619612,2,2-trifluoro-N-(4-phenylphenyl)acetamide

Product 1

HCID 86677207HCID 86677207, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

13.00 g (49.0 mmol) N-(Biphenyl-4-yl)-2,2,2-trifluoro-acetamide (II.1.a) is dissolved in 200 mL acetone and 13.5 g (98.0 mmol) potassium carbonate is added. 3.50 mL (55.7 mmol) methyl iodide is added and the mixture is stirred at RT over night. The solvent is evaporated. The residue is taken up in water and extracted with ethyl acetate. The organic phase is dried and the solvent is evaporated.

Workup

  1. customThe solvent is evaporated
  2. extractionextracted with ethyl acetate
  3. customThe organic phase is dried
  4. customthe solvent is evaporated

Sources & evidence

ORD record
ord-a56ad138d1d54046b17a39680d8b0f0e
Source dataset
uspto-grants-2013_12
Patent number
US08614238B2

Reaction notes

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