Water → HCID 71270269, compound

HRID 1914812Notes

Reaction equation

HRID 1914812 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]([N:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]3[CH:21]=2)=[CH:9][CH:8]=1)C)=[O:4].C(=O)([O-])[O-:25].[K+].[K+].O>CO>[F:1][C:2]([F:23])([F:22])[C:3]([OH:25])=[O:4].[N:14]1[C:13]([C:10]2[CH:11]=[CH:12][C:7]([NH:5][CH3:3])=[CH:8][CH:9]=2)=[CH:21][N:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=12

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 86677208HCID 86677208, compound

Product 1

HCID 71270269HCID 71270269, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.75 g (2.35 mmol) 2,2,2-Trifluoro-N-(4-imidazo[1,2-a]pyridin-2-yl-phenyl)-N-methyl-acetamide (educt IV.2.d) and 0.65 g (4.70 mmol) potassium carbonate are suspended in 20 mL methanol and 20 mL water and stirred at 50° C. over night. The mixture is extracted with ethyl acetate. The organic phase is dried and evaporated.

Workup

  1. extractionThe mixture is extracted with ethyl acetate
  2. customThe organic phase is dried
  3. customevaporated

Sources & evidence

ORD record
ord-d48d1d383c3642fcb23954e086ed3289
Source dataset
uspto-grants-2013_12
Patent number
US08614238B2

Reaction notes

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