Trifluoroacetic acid → HCID 46940149, compound

HRID 1914819Notes

Reaction equation

HRID 1914819 reaction equation
C(OC(=O)[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[N:27]=[C:26]4[C:21]([CH:22]=[N:23][C:24]5[N:25]4[N:28]=[C:29]([CH3:31])[CH:30]=5)=[CH:20][C:19]=3[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:31][C:29]1[CH:30]=[C:24]2[N:23]=[CH:22][C:21]3[CH:20]=[C:19]([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[C:18]([C:15]4[CH:14]=[CH:13][C:12]([C:8]5([NH2:7])[CH2:11][CH2:10][CH2:9]5)=[CH:17][CH:16]=4)=[N:27][C:26]=3[N:25]2[N:28]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58034383HCID 58034383, compound

Product 1

HCID 46940149HCID 46940149, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of Compound (4-2) (7 mg, 0.14 mmol, 1 eq.) in CH2Cl2 (3 mL) was added trifluoroacetic acid (1 mL) and the mixture stirred at room temperature for 15 minutes. The volatiles were removed under reduced pressure and the residue was purified by reverse phase HPLC using TFA:CH3CN and water as the eluant to provide Compound (4-3). MS (M+H)+: observed=406.2027, calculated=406.2032

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customthe residue was purified by reverse phase

Sources & evidence

ORD record
ord-54c592b646cb46b79de8308b9ff3352d
Source dataset
uspto-grants-2013_12
Patent number
US08614221B2

Reaction notes

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