Hydrazine hydrate (1:1) → HCID 58034303, compound

HRID 1914826Notes

Reaction equation

HRID 1914826 reaction equation
[NH2:1][C:2]1[N:7]2[N:8]=[C:9]([CH3:11])[CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:12]([O:14]C)=O.O.[NH2:17][NH2:18]>CCO>[NH2:1][C:2]1[N:7]2[N:8]=[C:9]([CH3:11])[CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:12]([NH:17][NH2:18])=[O:14]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2763438methyl 7-amino-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

Product 1

HCID 58034303HCID 58034303, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 250 mL flask containing the Methyl 7-amino-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate (2.1 g, 20 mmol), EtOH (55 mL), and hydrazine hydrate (20 mL) was heated to reflux for 6 hours. The mixture was allowed to cool to room temperature. The precipitated solid was filtered and washed with water (2×10 mL) to provide Compound (10-1) as a white solid.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 6 hours
  3. filtrationThe precipitated solid was filtered
  4. washwashed with water (2×10 mL)

Sources & evidence

ORD record
ord-701308f0b71d4f668a7c97a6b42563de
Source dataset
uspto-grants-2013_12
Patent number
US08614221B2

Reaction notes

Loading…