Hydrochloric Acid → HCID 58034299, compound

HRID 1914828Notes

Reaction equation

HRID 1914828 reaction equation
[CH3:1][C:2]1[CH:14]=[C:5]2[N:6]=[CH:7][C:8]3[NH:9]C(=O)[NH:11][C:12]=3[N:4]2[N:3]=1.Cl>>[CH3:1][C:2]1[CH:14]=[C:5]2[N:6]=[CH:7][C:8]([NH2:9])=[C:12]([NH2:11])[N:4]2[N:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 136133180HCID 136133180, compound

Product 1

HCID 58034299HCID 58034299, compound

Conditions

Temperature
100 °C

Procedure

A 40 mL scintillation vial containing Compound (10-2) (0.72 g, 3.8 mmol) and 10% aqueous HCl (25 mL) was heated at 100° C. for 3 hours. The mixture was allowed to cool, the solvent was removed in vacuo and water (˜40 mL) was added. The resulting solid (starting material) was filtered to recover Compound (10-2). The filtrate was then concentrated and dried to furnish Compound (10-3) as a yellowish solid.

Workup

  1. temperatureto cool
  2. customthe solvent was removed in vacuo and water (˜40 mL)
  3. additionwas added
  4. filtrationThe resulting solid (starting material) was filtered
  5. customto recover Compound (10-2)
  6. concentrationThe filtrate was then concentrated
  7. customdried

Sources & evidence

ORD record
ord-2bf87573521c4a43885a5ac416d66ceb
Source dataset
uspto-grants-2013_12
Patent number
US08614221B2

Reaction notes

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