HCID 52945927, compound → HCID 54768028, compound

HRID 1914862Notes

Reaction equation

HRID 1914862 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][C:13]=3[N:14]=2)=[CH:5][CH:4]=1)[CH3:2].[H][H]>[Pd].CO>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][C:13]=3[N:14]=2)=[CH:7][CH:8]=1)[CH3:2]

Participants

5

Reactant 2

HCID 52945927HCID 52945927, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54768028HCID 54768028, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

20 mL of methanol was slowly added dropwise to the compound (b) prepared in Preparation 2 (1.31 mmol, 1 eq) and 5% Pd/C (0.4 g), and then the reaction mixture was charged with hydrogen and stirred at room temperature for 24 hours.

Sources & evidence

ORD record
ord-c2b17ff91e9847e6823d035bf45e0eca
Source dataset
uspto-grants-2013_12
Patent number
US08614240B2

Reaction notes

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