反应详情

Intermediate I-23a was prepared from 4,5-difluoro-6-(2-fluoro-4-iodo-phenyl)-2-methyl-6,8-dihydro-imidazo[4′,5′:3,4]benzo[1,2-d]oxazol-7-one (I-18a: 80 mg, 0.178 mmol), N,N-dimethylaminosulfonyl chloride (38.5 mg, 0.269 mmol), TEA (54.5 mg, 0.534 mmol) and DMAP (10 mg) using procedures analogous to those described above for Intermediate I-19a to afford the 60 mg of the product (61.2% yield). H1NMR (CDCl3, 300 MHz): δ 7.70-7.64 (m, 2H), 7.30-7.22 (m, 1H), 3.20 (s, 6H), 2.72 (s, 3H). LCMS: 70.3%, m/z=552.9 (M+1). HPLC: 81.3%.