HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → (1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride | HCID 12138182 | — |
| Reactant | (1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid | HCID 12138189 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | (1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride | HCID 12138190 | 73% |
Reaction Steps
(1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride (16) is prepared similarly to compound (9) from compound (15) and phosphorus pentachloride in dry benzene. The acid chloride that is obtained is immediately used for further reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614317B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-37bd0ec4612246d6abbed01f9b4f61f0 |
| Source note | uspto-grants-2013_12 |