Hydrochloric Acid → HCID 51001042, compound

HRID 1915076Notes

Reaction equation

HRID 1915076 reaction equation
[CH3:1][S:2]([CH2:36][CH2:37][CH2:38][C:39]([O:41]C)=[O:40])(=[N:4][C:5]([C:7]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([O:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[CH:30]=4)=[O:27])=[CH:21][CH:20]=3)[CH:15]=[CH:14][N:13]=2)[NH:9][CH:8]=1)=[O:6])=[O:3].[OH-].[Na+].O.Cl>CO>[CH3:1][S:2]([CH2:36][CH2:37][CH2:38][C:39]([OH:41])=[O:40])(=[N:4][C:5]([C:7]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([O:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[CH:30]=4)=[O:27])=[CH:21][CH:20]=3)[CH:15]=[CH:14][N:13]=2)[NH:9][CH:8]=1)=[O:6])=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 73669719HCID 73669719, compound

Product 1

HCID 51001042HCID 51001042, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of methyl 4-{S-methyl-N-[(5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrol-3-yl)carbonyl]sulfonimidoyl}butanoate (5 mg, 0.0087 mol) in MeOH (3 ml) was added 1M NaOH (0.5 ml, 0.5 mmol). The mixture was stirred at room temperature for 30 minutes, and poured into 30 ml of water. 2M HCl was added dropwise until pH=4. The precipitates were filtered, washed with water and dried to give 4-{S-methyl-N-[(5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrol-3-yl)carbonyl]sulfonimidoyl}butanoic acid as off-white solid. Yield: 5 mg, 100%.

Workup

  1. filtrationThe precipitates were filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-653c87b2032c482fb9c05627a6334229
Source dataset
uspto-grants-2013_12
Patent number
US08614234B2

Reaction notes

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