Acetic Acid → HCID 77231503, compound

HRID 1915531Notes

Reaction equation

HRID 1915531 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6](Cl)[N:5]2[N:15]=[CH:16][N:17]=[C:4]2[N:3]=1.C(O)(=O)C.CO>C1COCC1>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][N:5]2[N:15]=[CH:16][N:17]=[C:4]2[N:3]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 887MethanolHCID 11149750HCID 11149750, compound

Product 1

HCID 77231503HCID 77231503, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 0.5 g 5,7-dichloro-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidine, 0.22 ml glacial acetic acid, 0.5 ml methanol, 3 ml THF and 366 mg of Zn/Cu pair are stirred for 3 h at ambient temperature. The mixture is filtered through celite, evaporated to dryness and the residue is purified on silica gel (dichloromethane/ethyl acetate) to yield the desired product.

Workup

  1. filtrationThe mixture is filtered through celite
  2. customevaporated to dryness
  3. customthe residue is purified on silica gel (dichloromethane/ethyl acetate)

Sources & evidence

ORD record
ord-e3ce4572cb424ba1a5d33c58232d4ea7
Source dataset
uspto-grants-2013_12
Patent number
US08614218B2

Reaction notes

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