N,N-Dimethylaniline → HCID 86630683, compound

HRID 1915578Notes

Reaction equation

HRID 1915578 reaction equation
[CH3:1][C:2]1[N:18]=[C:5]2[N:6]=[C:7](O)[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[C:9]([CH3:10])[N:4]2[N:3]=1.CN(C)C1C=CC=CC=1.O=P(Cl)(Cl)[Cl:30]>>[Cl:30][C:7]1[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:9]([CH3:10])[N:4]2[N:3]=[C:2]([CH3:1])[N:18]=[C:5]2[N:6]=1

Participants

4

Reactant 3

HCID 949N,N-DimethylanilineHCID 24813Phosphorus oxychlorideHCID 178432406HCID 178432406, compound

Product 1

HCID 86630683HCID 86630683, compound

Conditions

Temperature
100 °C

Procedure

1.34 g of the product of step 1 are suspended in 20 ml POCl3. 1.06 ml N,N-dimethylaniline is added and the mixture is heated to 100° C. for 45 min. The excess of POCl3 is removed by distillation and the residue is treated with ice. The desired product precipitates and is collected by filtration.

Workup

  1. customThe excess of POCl3 is removed by distillation
  2. additionthe residue is treated with ice
  3. customThe desired product precipitates
  4. filtrationis collected by filtration

Sources & evidence

ORD record
ord-644e4f65e6c74c72b5b7580f5e630912
Source dataset
uspto-grants-2013_12
Patent number
US08614218B2

Reaction notes

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