反应详情

A solution of 5.00 g 3-amino-5-ethyl-1,2,4-triazole and 15.00 g diethyl phenylmalonate in 18 ml N,N-dibutylbutan-1-amine is stirred at 185° C. over night. The solution is diluted with 5N NaOH solution, the resulting mixture is stirred for 30 min. The aqueous layer is washed with diethylether, acidified at 0° C. with concentrated HCl until precipition of the product is complete. The precipitate is collected by filtration to yield the product, which is used without further purification.

1. washThe aqueous layer is washed with diethylether
2. customacidified at 0° C. with concentrated HCl until precipition of the product
3. filtrationThe precipitate is collected by filtration
4. customto yield the product, which
5. customis used without further purification