Hydrochloric Acid → HCID 178478299, compound

HRID 1915588Notes

Reaction equation

HRID 1915588 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]=[C:17]([C:19]3[S:20][CH:21]=[CH:22][N:23]=3)[NH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24].CO>O1CCOCC1>[ClH:24].[S:20]1[CH:21]=[CH:22][N:23]=[C:19]1[C:17]1[NH:16][N:15]=[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:18]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178451829HCID 178451829, compound

Product 1

HCID 178478299HCID 178478299, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The mixture of 7.59 g of the crude product obtained in step 4 is dissolved in dioxane and 68 ml hydrogen chloride 4M sol. in dioxane is added slowly. The product appears as an oil. After addition of 542 ml methanol the oil is dissolved. The solution is stirred over night until precipitation of the crystalline product.

Workup

  1. dissolutionis dissolved

Sources & evidence

ORD record
ord-e330394d95634ff68e7404c5a666dd86
Source dataset
uspto-grants-2013_12
Patent number
US08614218B2

Reaction notes

Loading…