Hydrazine hydrate (1:1) → 1H-pyrrole-2-carbohydrazonamide

HRID 1915611Notes

Reaction equation

HRID 1915611 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].O.[NH2:12][NH2:13]>C(O)C.O>[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:12][NH2:13])[NH2:7]

Participants

6

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 138277Pyrrole-2-carbonitrileHCID 10942334Sodium Methoxide

Product 1

HCID 1363872481H-pyrrole-2-carbohydrazonamide

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 10 g 1H-pyrrole-2-carbonitrile and 1 eq sodium methoxide in 20 ml ethanol and stirred for 10 min. Hydrazine hydrate (3 eq.) is then added and resulting reaction mixture is stirred at room temperature for 18 h. The Reaction mixture is then diluted with water, extracted with ethyl acetate, dried over Na2SO4 and concentrated under vacuum to yield desired compound.

Workup

  1. customresulting
  2. customreaction mixture
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-67f49f9b5f824120a12b4e9160bbdb77
Source dataset
uspto-grants-2013_12
Patent number
US08614218B2

Reaction notes

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