(S)-1-Boc-3-methylpiperazine → HCID 86679980, compound

HRID 1915769Notes

Reaction equation

HRID 1915769 reaction equation
Cl[C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[N+:8]([O-])=O.[CH3:11][C@@H:12]1[NH:17][CH2:16][CH2:15][N:14]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:13]1>>[NH2:8][C:3]1[CH:4]=[N:5][N:6]([CH3:7])[C:2]=1[N:17]1[CH2:16][CH2:15][N:14]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:13][C@@H:12]1[CH3:11]

Participants

3

Reactant 2

HCID 7023035(S)-1-Boc-3-methylpiperazineHCID 123448365-chloro-1-methyl-4-nitro-1H-pyrazole

Product 1

HCID 86679980HCID 86679980, compound

Procedure

Following the procedure for Intermediate 10 starting from 5-chloro-1-methyl-4-nitro-1H-pyrazole from Example 1 and (S)-tert-butyl 3-methylpiperazine-1-carboxylate gave (S)-tert-butyl 4-(4-amino-1-methyl-1H-pyrazol-5-yl)-3-methylpiperazine-1-carboxylate as an orange gum (134 mg, 73% over two steps). LCMS (ES+) m/z 296 (M+1).

Sources & evidence

ORD record
ord-c3259eb75e824fde86a89e51b09b69d0
Source dataset
uspto-grants-2013_12
Patent number
US08614206B2

Reaction notes

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