HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-bromo-1-methyl-4-nitro-1H-pyrazole → tert-butyl 4-(1-methyl-4-nitro-1H-pyrazol-5-yl)-5-oxo-1,4-diazepane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-bromo-1-methyl-4-nitro-1H-pyrazole | HCID 1279587 | — |
| Reactant | 5-Oxo-(1,4)diazepane-1-carboxylic acid tert-butyl ester | HCID 22617736 | — |
| Product | tert-butyl 4-(1-methyl-4-nitro-1H-pyrazol-5-yl)-5-oxo-1,4-diazepane-1-carboxylate | HCID 86680013 | 33% |
Reaction Steps
Following the procedure for Intermediate 202 starting from 5-bromo-1-methyl-4-nitro-1H-pyrazole and tert-butyl 5-oxo-1,4-diazepane-1-carboxylate gave tert-butyl 4-(1-methyl-4-nitro-1H-pyrazol-5-yl)-5-oxo-1,4-diazepane-1-carboxylate as a brown gum (136 mg, 33%). 1H NMR (400 MHz, d4-MeOD) δ 8.18 (s, 1H), 4.04-3.72 (m, 5H), 3.90-3.62 (m, 4H), 3.02-2.86 (m, 2H), 1.52 (s, 9H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614206B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-e7af3e9c098a466b99c4509037fa249c |
| Source note | uspto-grants-2013_12 |