HCID 86680072, compound → HCID 86679999, compound

HRID 1915862Notes

Reaction equation

HRID 1915862 reaction equation
[F:1][CH:2]1[CH2:8][CH2:7][N:6]([C:9]2[N:13]([CH3:14])[N:12]=[CH:11][C:10]=2[N+:15]([O-:17])=[O:16])[CH2:5][CH2:4][CH:3]1[NH:18]C(=O)OC(C)(C)C>CO.[Pd]>[F:1][CH:2]1[CH2:8][CH2:7][N:6]([C:9]2[N:13]([CH3:14])[N:12]=[CH:11][C:10]=2[N+:15]([O-:17])=[O:16])[CH2:5][CH2:4][CH:3]1[NH2:18]

Participants

4

Reactant 1

HCID 86680072HCID 86680072, compound

Product 1

HCID 86679999HCID 86679999, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of tert-butyl 5-fluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepan-4-ylcarbamate (65 mg, 0.182 mmol) in MeOH (20 mL) was passed through the H-Cube® (full H2, 50° C., flow rate: 1 mL/min, 30 mm 10% Pd/C cartridge). The solvent was removed under reduced pressure to give the free amine, 5-fluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepan-4-amine, as a pale yellow glass (51 mg).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-321a0a7a8d054f6fb1ed611d32deee1f
Source dataset
uspto-grants-2013_12
Patent number
US08614206B2

Reaction notes

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