3-Methoxy-4-hydroxyphenylethylamine hydrochloride → N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-4-methyl-1,2-dithiolane-4-carboxamide

HRID 1915988Notes

Reaction equation

HRID 1915988 reaction equation
OC1C=CC(CN[C:8]([C:10]2([CH3:15])[CH2:14][S:13][S:12][CH2:11]2)=[O:9])=CC=1OC.Cl.[NH2:21][CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[C:26]([O:31][CH3:32])[CH:25]=1>>[OH:30][C:27]1[CH:28]=[CH:29][C:24]([CH2:23][CH2:22][NH:21][C:8]([C:10]2([CH3:15])[CH2:14][S:13][S:12][CH2:11]2)=[O:9])=[CH:25][C:26]=1[O:31][CH3:32]

Participants

3

Reactant 2

HCID 119576213-Methoxy-4-hydroxyphenylethylamine hydrochlorideHCID 45111293N-(4-hydroxy-3-methoxybenzyl)-4-methyl-1,2-dithiolane-4-carboxamide

Product 1

HCID 45111294N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-4-methyl-1,2-dithiolane-4-carboxamideYield 64%

Procedure

Same method as for Compound 16 with 4-(2-aminoethyl)-2-methoxyphenol hydrochloride. 320 mg of a yellow solid are obtained (yield=64%).

Sources & evidence

ORD record
ord-609bc5c0944a4ed7b18a31f7b0d3282c
Source dataset
uspto-grants-2013_12
Patent number
US08617524B2

Reaction notes

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