Hydrochloric Acid → Sodium hydroxide rebamipide

Participants

Reaction Steps

366 mL of 10 N hydrochloric acid (432 g, 3.66 mol) and 7.8 L of 7.67% (w/v) aqueous solution of HPMC (grade: TC-5EW (viscosity of 2% (w/v) aqueous solution: 3 mm2/s)) were mixed to prepare a solution of hydrochloric acid-HPMC (TC-5EW). To 21 L of aqueous sodium hydroxide which was prepared by adding purified water to 132 g of sodium hydroxide (3.3 mol), 600 g of rebamipide (1.62 mol) was added and dissolved with heating to give a sodium hydroxide-rebamipide solution.

Provenance & Evidence