Hydrochloric Acid → Sodium hydroxide rebamipide

HRID 1916005Notes

Reaction equation

HRID 1916005 reaction equation
Cl.[OH-].[Na+:3].[CH:4]1[CH:5]=[CH:6][C:7]2[NH:14][C:12](=[O:13])[CH:11]=[C:10]([CH2:15][CH:16]([NH:20][C:21]([C:23]3[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=3)=[O:22])[C:17]([OH:19])=[O:18])[C:8]=2[CH:9]=1>O>[OH-:13].[Na+:3].[CH:4]1[CH:5]=[CH:6][C:7]2[NH:14][C:12](=[O:13])[CH:11]=[C:10]([CH2:15][CH:16]([NH:20][C:21]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[O:22])[C:17]([OH:19])=[O:18])[C:8]=2[CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5042RebamipideHCID 14798Sodium Hydroxide2×

Product 1

HCID 68327531Sodium hydroxide rebamipide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

366 mL of 10 N hydrochloric acid (432 g, 3.66 mol) and 7.8 L of 7.67% (w/v) aqueous solution of HPMC (grade: TC-5EW (viscosity of 2% (w/v) aqueous solution: 3 mm2/s)) were mixed to prepare a solution of hydrochloric acid-HPMC (TC-5EW). To 21 L of aqueous sodium hydroxide which was prepared by adding purified water to 132 g of sodium hydroxide (3.3 mol), 600 g of rebamipide (1.62 mol) was added and dissolved with heating to give a sodium hydroxide-rebamipide solution.

Workup

  1. additionby adding
  2. additionwas added
  3. dissolutiondissolved
  4. temperaturewith heating

Sources & evidence

ORD record
ord-d898feb0c1d7429395e3dccd7f7fd5b4
Source dataset
uspto-grants-2013_12
Patent number
US08617606B2

Reaction notes

Loading…