Hydrochloric Acid → HCID 67385864, compound

HRID 1916089Notes

Reaction equation

HRID 1916089 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:13][C@@H:12]([CH3:14])[CH2:11][N:10]([C:15](=[O:17])[CH3:16])[CH2:9]1)(C)(C)C.[ClH:19].O1CCOCC1>C(Cl)Cl>[ClH:19].[NH2:7][C@@H:8]1[CH2:13][C@@H:12]([CH3:14])[CH2:11][N:10]([C:15](=[O:17])[CH3:16])[CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67385284HCID 67385284, compound

Product 1

HCID 67385864HCID 67385864, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

((3R,5R)-1-Acetyl-5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester (0.5 g, 1.971 mmol) was dissolved in DCM (15 ml) and HCl 4M in dioxane (2.5 ml, 10 mmol) was added. The resulting colorless solution was stirred at RT until precipitation of a solid was observed. The solvent was evaporated and the residue was dried under high vacuum. To give 0.45 g of 1-((3R,5R)-3-amino-5-methyl-piperidin-1-yl)-ethanone hydrochloride as an off-white solid (>95% yield).

Workup

  1. customThe solvent was evaporated
  2. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-a6bd4fce9b90470f8828370a069bbe47
Source dataset
uspto-grants-2013_12
Patent number
US08618103B2

Reaction notes

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