Hydrochloric Acid → HCID 67386202, compound

HRID 1916092Notes

Reaction equation

HRID 1916092 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][C@H:15]([CH3:17])[CH2:14][C@@H:13]([NH:18]C(OC(C)(C)C)=O)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:26].O1CCOCC1>C(Cl)Cl>[ClH:26].[CH2:1]([O:8][C:9]([N:11]1[CH2:16][C@H:15]([CH3:17])[CH2:14][C@@H:13]([NH2:18])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67385303HCID 67385303, compound

Product 1

HCID 67386202HCID 67386202, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(3R,5R)-3-tert-Butoxycarbonylamino-5-methyl-piperidine-1-carboxylic acid benzyl ester (3.25 g, 9.327 mmol) was dissolved in DCM (50 ml) and HCl 4M in dioxane (20 ml, 80 mmol) was added. The resulting colorless solution stirred at RT for 4 hours before being evaporated. The residue was dried under high vacuum overnight to give 2.89 g of (3R,5R)-3-amino-5-methyl-piperidine-1-carboxylic acid benzyl ester hydrochloride as a white foam (>95% yield).

Workup

  1. custombefore being evaporated
  2. customThe residue was dried under high vacuum overnight

Sources & evidence

ORD record
ord-17b16e4ee0b744b4ab7d8097f823edf8
Source dataset
uspto-grants-2013_12
Patent number
US08618103B2

Reaction notes

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