反应详情

(1-Cyclopropylmethanesulfonyl-piperidin-3-yl)-[6-methyl-3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-pyridin-2-yl]-amine was prepared from (1-cyclopropylmethanesulfonyl-piperidin-3-yl)-{6-methyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine using 20 equivalents of tetrabutyl ammonium fluoride 1 M solution in THF, and 20 equivalents of ethylenediamine, and warming the mixture at 70° C. for 5 h.