Potassium Carbonate → 2-Pyridinamine, 5-ethynyl-4-methyl-

HRID 1916184Notes

Reaction equation

HRID 1916184 reaction equation
[CH3:1][C:2]1[C:7]([C:8]#[C:9][Si](C)(C)C)=[CH:6][N:5]=[C:4]([NH2:14])[CH:3]=1.C([O-])([O-])=O.[K+].[K+]>CO>[C:8]([C:7]1[C:2]([CH3:1])=[CH:3][C:4]([NH2:14])=[N:5][CH:6]=1)#[CH:9]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58072883HCID 58072883, compound

Product 1

HCID 99641002-Pyridinamine, 5-ethynyl-4-methyl-

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound is synthesized according to general procedure GP3 starting from to 1.8 g (8.8 mmol) 4-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 609 mg (4.4 mmol) K2CO3 in 315 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 1.0 g (86%).

Workup

  1. customThe product is purified by chromatography on silica gel using a DCM/MeOH gradient

Sources & evidence

ORD record
ord-640ae0b3c3cb46f7859281b640ba0fc4
Source dataset
uspto-grants-2013_12
Patent number
US08618111B2

Reaction notes

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