Potassium Carbonate → 4-Ethyl-5-ethynylpyridin-2-amine

HRID 1916186Notes

Reaction equation

HRID 1916186 reaction equation
[CH2:1]([C:3]1[C:8]([C:9]#[C:10][Si](C)(C)C)=[CH:7][N:6]=[C:5]([NH2:15])[CH:4]=1)[CH3:2].C([O-])([O-])=O.[K+].[K+]>CO>[CH2:1]([C:3]1[C:8]([C:9]#[CH:10])=[CH:7][N:6]=[C:5]([NH2:15])[CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58072749HCID 58072749, compound

Product 1

HCID 574162984-Ethyl-5-ethynylpyridin-2-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound is synthesized according to general procedure GP3 starting from 3.3 g (15 mmol) 4-ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 1.04 g (7.5 mmol) K2CO3 in 30 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 1.78 g (81%).

Workup

  1. customThe product is purified by chromatography on silica gel using a DCM/MeOH gradient

Sources & evidence

ORD record
ord-b78c03d699024a24936a26f0a2956554
Source dataset
uspto-grants-2013_12
Patent number
US08618111B2

Reaction notes

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