Methyl iodide → HCID 66885614, compound

HRID 1916227Notes

Reaction equation

HRID 1916227 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]4[CH:21]=[C:22]5[C:27](=[CH:28][CH:29]=4)[C:26](=[O:30])[N:25]([CH3:31])[CH:24]=[CH:23]5)[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.S1C=CC2C(N3CCN(CCCOC4C=C5C(=CC=4)C(=O)NC=C5)CC3)=CC=CC1=2.CI.C(O)C.[ClH:67]>C(OCC)(=O)C>[ClH:67].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]4[CH:21]=[C:22]5[C:27](=[CH:28][CH:29]=4)[C:26](=[O:30])[N:25]([CH3:31])[CH:24]=[CH:23]5)[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 21887872Ethanol hydrochlorideHCID 66885604HCID 66885604, compoundHCID 66885615HCID 66885615, compound

Product 1

HCID 66885614HCID 66885614, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By a similar method as in Example 18, 6-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-2H-isoquinolin-1-one was prepared from 6-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2H-isoquinolin-1-one using methyl iodide, and after it was made into an ethyl acetate solution, 1N hydrochloric acid ethanol solution was added thereto, precipitated crystals were separated by filtration, recrystallized from ethyl acetate and thereby 6-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-2H-isoquinolin-1-one hydrochloride was obtained in the form of a white powder.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration
  4. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-dbb33064ed1a457ba669d311658f24fa
Source dataset
uspto-grants-2013_12
Patent number
US08618109B2

Reaction notes

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