p-Toluenesulfonic acid monohydrate → 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one p-toluenesulfonate

HRID 1916233Notes

Reaction equation

HRID 1916233 reaction equation
O.[C:2]1([CH3:12])[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[S:13]1[CH:17]=[CH:16][C:15]2[C:18]([N:22]3[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][CH2:30][CH2:31][O:32][C:33]4[CH:42]=[C:41]5[C:36]([CH:37]=[CH:38][C:39](=[O:43])[NH:40]5)=[CH:35][CH:34]=4)[CH2:24][CH2:23]3)=[CH:19][CH:20]=[CH:21][C:14]1=2>CO.ClCCl>[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1.[S:13]1[CH:17]=[CH:16][C:15]2[C:18]([N:22]3[CH2:23][CH2:24][N:25]([CH2:28][CH2:29][CH2:30][CH2:31][O:32][C:33]4[CH:42]=[C:41]5[C:36]([CH:37]=[CH:38][C:39](=[O:43])[NH:40]5)=[CH:35][CH:34]=4)[CH2:26][CH2:27]3)=[CH:19][CH:20]=[CH:21][C:14]1=2

Participants

5

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 11978813Brexpiprazole

Product 1

HCID 866546927-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one p-toluenesulfonate

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

p-Toluenesulfonic acid monohydrate was added to a solution of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one in methanol and dichloromethane and the solvent was evaporated under reduced pressure. The residue was recrystallized from methanol and thereby 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one p-toluenesulfonate was obtained in the form of a white powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-f7e5e5d688e3481982cdf6d4fccafde7
Source dataset
uspto-grants-2013_12
Patent number
US08618109B2

Reaction notes

Loading…