反应详情

温度

170 °C

A suspension of 2-amino-1H-indole-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester (259 mg, 1 mmol) and ammonium formate (62 mg, 1 mmol) in 2 mL formamide was heated under an atmosphere of nitrogen to 170° C. overnight. On cooling to room temperature, water was added and the resulting precipitate was collected by filtration and dried in a vacuum oven for 4 hours to a constant weight to give the title compound (103 mg, 0.42 mmol). LC-MS (1) Rt 1.27 min; m/z (ES−) 242.

1. temperatureOn cooling to room temperature
2. filtrationthe resulting precipitate was collected by filtration
3. customdried in a vacuum oven for 4 hours to a constant weight