反应详情

温度

90 °C

A mixture of 4-hydroxy-9H-pyrimido[4,5-b]indole-7-carboxylic acid methyl ester (215 mg, 0.88 mmol) and POCl3 (2 mL) was heated at 90° C. for 2 hours. Upon cooling the reaction mixture was concentrated in vacuo to give the title compound and used immediately in the subsequent synthesis. LC-MS (1) Rt 1.79 min; m/z (ES+) 262/264.

1. temperatureUpon cooling the reaction mixture
2. concentrationwas concentrated in vacuo