関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | 8-(Bromomethyl)-7-fluoro-2-(methyloxy)quinoline | HCID 66737650 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [7-Fluoro-2-(methyloxy)-8-quinolinyl]acetonitrile | HCID 67130956 | 100.8% |
反応手順
To a solution of 8-bromomethyl-7-fluoro-2-methoxy-quinoline (20.0 g, 74 mmol; prepared as in WO 2007/081597) in DMF (530 mL) was added KCN (22.1 g, 339 mmol) and the mixture was stirred at 70° C. overnight. The mixture was concentrated, water and EA were added and the aq. layer was extracted with EA. The combined org layers were washed with brine, dried over MgSO4 and concentrated to afford the title intermediate as a beige solid (16.13 g, 100% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08618092B2 |
|---|
| 出典データセット | uspto-grants-2013_12 |
|---|
| ORD ID | ord-a62d0afbb6674d8dbdfe33d2a44996be |
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| 出典メモ | uspto-grants-2013_12 |
|---|
