反应详情

温度

70 °C

To a solution of 8-bromomethyl-7-fluoro-2-methoxy-quinoline (20.0 g, 74 mmol; prepared as in WO 2007/081597) in DMF (530 mL) was added KCN (22.1 g, 339 mmol) and the mixture was stirred at 70° C. overnight. The mixture was concentrated, water and EA were added and the aq. layer was extracted with EA. The combined org layers were washed with brine, dried over MgSO4 and concentrated to afford the title intermediate as a beige solid (16.13 g, 100% yield).

1. concentrationThe mixture was concentrated
2. additionwater and EA were added
3. extractionthe aq. layer was extracted with EA
4. washThe combined org layers were washed with brine
5. dry with materialdried over MgSO4
6. concentrationconcentrated