反应详情

温度

65 °C

To a mixture of 2-methoxy-4-nitrobenzaldehyde (10.0 g; 55.2 mmol) in 11 mL of water and 11 mL of acetone at 65° C. was added a 1% solution of NaOH (13.8 mL) over 30 minutes. The mixture was heated at 65° C. for 2 h, cooled in an ice bath and neutralized with 10% HCl. A solid precipitated which was filtered, washed with water and dried under vacuum to afford 12.2 g (100%) of the title compound as a reddish-brown solid. HPLC (Method #1) 2.48 min retention time, (80%); MS (ES): m/z 222 [M+H]+.

1. temperaturecooled in an ice bath
2. customA solid precipitated which
3. filtrationwas filtered
4. washwashed with water
5. customdried under vacuum