HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 17757392, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl (2-{[{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzyl}(1H-imidazol-2-ylmethyl)amino]methyl}-1H-imidazol-1-yl)acetate | HCID 23654397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 17757392 | HCID 17757392 | — |
Reaction Steps
To an ethanol (7.6 mL) solution of the compound (50 mg) obtained in Example 8, an aqueous 2N-sodium hydroxide solution (1.0 mL) was added. The reaction solution was stirred at room temperature for 30 minutes. The reaction solution was neutralized with 2N-hydrochloric acid (1.0 mL) added thereto and the solvent was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane:methanol=7:3) to obtain the title compound having the following physical properties (38 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618122B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-54e235bc1f3c4108a59f70dc40b40504 |
| Source note | uspto-grants-2013_12 |