Hydrochloric Acid → HCID 17757392, compound

HRID 1916377Notes

Reaction equation

HRID 1916377 reaction equation
[CH:1]1([N:7]2[CH2:43][CH2:42][C:10]3([CH2:14][N:13]([CH2:15][C:16]4[CH:41]=[CH:40][C:19]([CH2:20][N:21]([CH2:28][C:29]5[N:30]([CH2:34][C:35]([O:37]CC)=[O:36])[CH:31]=[CH:32][N:33]=5)[CH2:22][C:23]5[NH:24][CH:25]=[CH:26][N:27]=5)=[CH:18][CH:17]=4)[CH2:12][CH2:11]3)[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+].Cl>C(O)C>[CH:1]1([N:7]2[CH2:43][CH2:42][C:10]3([CH2:14][N:13]([CH2:15][C:16]4[CH:41]=[CH:40][C:19]([CH2:20][N:21]([CH2:28][C:29]5[N:30]([CH2:34][C:35]([OH:37])=[O:36])[CH:31]=[CH:32][N:33]=5)[CH2:22][C:23]5[NH:24][CH:25]=[CH:26][N:27]=5)=[CH:18][CH:17]=4)[CH2:12][CH2:11]3)[CH2:9][CH2:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23654397Ethyl (2-{[{4-[(8-cyclohexyl-2,8-diazaspiro[4.5]dec-2-yl)methyl]benzyl}(1H-imidazol-2-ylmethyl)amino]methyl}-1H-imidazol-1-yl)acetate

Product 1

HCID 17757392HCID 17757392, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To an ethanol (7.6 mL) solution of the compound (50 mg) obtained in Example 8, an aqueous 2N-sodium hydroxide solution (1.0 mL) was added. The reaction solution was stirred at room temperature for 30 minutes. The reaction solution was neutralized with 2N-hydrochloric acid (1.0 mL) added thereto and the solvent was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane:methanol=7:3) to obtain the title compound having the following physical properties (38 mg).

Workup

  1. additionadded
  2. concentrationthe solvent was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (dichloromethane:methanol=7:3)

Sources & evidence

ORD record
ord-54e235bc1f3c4108a59f70dc40b40504
Source dataset
uspto-grants-2013_12
Patent number
US08618122B2

Reaction notes

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