Ethanol → 2-amino-N-(3,4-difluorobenzyl)-3-(difluoromethoxy)propanamide

HRID 191655Notes

Reaction equation

[CH2:1]([N:8]([CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:27]1)[CH:9]([C:10](=[O:11])[NH:12][CH2:13][c:14]1[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]1)[CH2:22][O:23][CH:24]([F:25])[F:26])[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:41][C:42]([O:43][C:44](=[O:45])[CH3:46])=[O:47].[CH3:48][CH2:49][OH:50].[Cl:51][CH2:52][Cl:53].[OH-:54].[OH-:55].[Pd+2:56]>>[NH2:8][CH:9]([C:10](=[O:11])[NH:12][CH2:13][c:14]1[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]1)[CH2:22][O:23][CH:24]([F:25])[F:26]

Participants

Reactant 7

HCID 702Ethanol

HCID 961Hydroxide2×

HCID 6344Dichloromethane

HCID 7918Acetic Anhydride

HCID 8471Triethylamine

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 57539235HCID 57539235, compound

Product 1

HCID 685361582-amino-N-(3,4-difluorobenzyl)-3-(difluoromethoxy)propanamide

Sources & evidence

ORD record: ord-8210803f43c749b38a9f643adcf9e0e1
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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