Acetic Anhydride → HCID 10072176, compound

HRID 1916591Notes

Reaction equation

HRID 1916591 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]#[C:22][C:23]3[CH:24]=[CH:25][C:26]([NH:29][CH2:30][CH2:31][N:32]4[CH2:36][CH2:35][CH2:34][CH2:33]4)=[N:27][CH:28]=3)=[N:19][CH:20]=2)=[CH:11][CH:10]=1>C(Cl)Cl>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]#[C:22][C:23]3[CH:24]=[CH:25][C:26]([N:29]([CH2:30][CH2:31][N:32]4[CH2:33][CH2:34][CH2:35][CH2:36]4)[C:5](=[O:7])[CH3:6])=[N:27][CH:28]=3)=[N:19][CH:20]=2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 10250554{5-[5-(4-Chloro-phenyl)-pyridin-2-ylethynyl]-pyridin-2-yl}-(2-pyrrolidin-1-yl-ethyl)-amine

Product 1

HCID 10072176HCID 10072176, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

45 μL (0.48 mmol) acetic anhydride is added to a solution of 89 mg (0.22 mmol) {5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-pyridin-2-yl}-(2-pyrrolidin-1-yl-ethyl)-amine in 2 mL DCM. The reaction solution is stirred for 16 h at RT. The solvent is eliminated i.vac. and further purification is carried out by HPLC-MS.

Workup

  1. customand further purification

Sources & evidence

ORD record
ord-e1ac4f9df993489193c4372b18ea5fcb
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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